Yes, many angels use self‑directed IRAs or trusts, but you must avoid prohibited transactions (e.g., self‑dealing with “disqualified persons”) that can blow up the tax status of the account. Certain investments can generate UBTI/UBIT(unrelated business taxable income/tax), which may require filing Form 990‑T (your custodian often files, but you’re responsible for tax). Read the rules, mind conflicts, and use experienced custodians.
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Practical tips: don’t provide personal services to an IRA‑owned asset; don’t transact with disqualified persons; expect illiquidity and plan for administrative fees. When in doubt, seek tax counsel before wiring.